Long non-coding RNAs (lncRNAs) play critical roles in development and pathogenesis of various diseases. Notably, lncRNA-metastasis-associated lung adenocarcinoma transcript 1(MALAT1) is among the most essential lncRNAs affecting various processes, including cell proliferation and apoptosis. Moreover, complex interactions between MALAT1 and fibrosis have attracted research interest to understand the pathophysiology of fibrotic diseases. This literature review discusses the existing research on the correlations between MALAT1 and various fibrotic diseases, including hepatic, pulmonary, renal, and myocardial fibrosis, focusing on the underlying molecular mechanisms. Additionally, this review lists the currently available MALAT1-targeted agents, such as nucleic acid drugs and small-molecule inhibitors, highlighting potential targets and strategies for fibrotic diseases treatment.
Ran et al. (Thu,) studied this question.