August 4, 2025

Figure 6 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles

Key Points

OVCAR3 extracellular vesicles induce significant proteomic changes in fallopian tube epithelium over 14 days.
Twenty-five proteins were uniquely upregulated by OVCAR3 EVs, highlighting specific alterations.
The study utilized proteomics to compare EVs from treated and control tissues, demonstrating EV impact.
Findings suggest that extracellular vesicles play a pivotal role in reprogramming fallopian tube cells in ovarian cancer.

Abstract

Fallopian tube alters sEVs protein cargo after treatment with OVCAR3 EVs for 14 days. A, Diagram showing EV treatment of hFTE tissue and production of secondary-release EVs. B, Volcano plot showing proteomic changes in EVs derived from tissues treated with OVCAR3 EVs compared with PBS control. C, Volcano plot showing proteomics changes in EVs derived from tissues treated with FT240 EVs compared with PBS-treated controls. D, Venn diagram showing identification of 25 proteins exclusively upregulated by OVCAR3 EVs only. E, Venn diagram showing detection of DEPs not present in original OVCAR3 EVs in hFTE-derived EVs. F, GO biological pathway analysis of DEPs in hFTE-derived secondary-release EVs following stimulation with OVCAR3 EVs.

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Figure 6 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles

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