The objective of research was development of analytical method for simultaneous estimation of two drugs in combination; that is available commercially as tablets. Various approaches were tried for the combination. When spectrophotometric, colorimetric, fluorimetric, spectro-fluorimetric methods did not show any promise, the planar chromatographic technique was successfully developed and validated. The details of development work, difficulties encountered, method development, optimization and validation is discussed
Damle et al. (Tue,) studied this question.