January 1, 2025Open Access

Synthesis, evaluation of in vitro cytotoxic activity, and in silico studies of some 3-methylenamino-4(3H)-quinazolone derivatives

Key Points

Compounds 5, 6, and 7 exhibited significant cytotoxic effects against RD and MDA-MB-231 cells, with low toxicity to normal cells.
Cytotoxicity results showed strong binding to EGFR, indicating potential for targeted cancer treatments in future studies.
Twenty novel quinazolone derivatives were synthesized through imine formation, demonstrating promise for cancer applications.
Good ADMET profiles suggest these derivatives may lead to viable therapeutic options, yet further studies are warranted.

Abstract

Twenty 3-methylenamino-4(3 H )-quinazolone derivatives were synthesized via imine formation. Compounds 5, 6, and 7 showed potent cytotoxicity against RD and MDA-MB-231, low toxicity to normal cells, and strong EGFR binding, with good ADMET profiles.

Synthesis, evaluation of in vitro cytotoxic activity, and in silico studies of some 3-methylenamino-4(3H)-quinazolone derivatives

Key Points

Abstract

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