Figure S8 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models

Key Points

• Co-targeting Bcl-xL and Mcl-1 exhibited notable synergistic effects in CRPC models, enhancing effectiveness.
• XZ739 demonstrated single agent activity in 2D culture models, highlighting its potential as an effective treatment option.
• The research utilized AR-V7-expressing CRPC models to assess the impact of targeting Bcl-xL and Mcl-1 jointly.
• Findings indicate that such co-targeting strategies may lead to improved outcomes for patients with CRPC.