What type of study is this?

September 5, 2025Open Access

Palladium-Catalyzed Allylic C–F Bond Functionalization of Pentafluoroethyl Alkenes with Heteroatom Nucleophiles

ZFZhengjie FuChinese University of Hong Kong GTGavin Chit TsuiChinese University of Hong Kong

Key Points

The reaction results in the formation of new C–N and C–O bonds through C–F bond cleavage.
Diastereoselectivity reaches good to excellent levels when synthesizing tetra- and trisubstituted alkenes.
Pentafluoroethyl alkenes can be used as versatile substrates in this palladium-catalyzed reaction.
A range of heteroatom nucleophiles, including amines and thiols, can be effectively employed.

Abstract

A diastereoselective Pd-catalyzed allylic C–F bond functionalization of pentafluoroethyl alkenes is described. Heteroatom nucleophiles including amines, alcohols, and thiols can be employed to construct new C–N, C–O, or C–S bonds with concomitant cleavage of an allylic C–F bond. Both 1,1- and 1,2-disubstituted pentafluoroalkenes can be utilized to synthesize novel tetra- and trisubstituted alkenes containing an sp2-carbon connected to both F and CF3 in good to excellent diastereoselectivities.

اسأل الذكاء الاصطناعي

Bookmark

View Full Paper

Cite This Study

Fu et al. (Mon,) studied this question.

synapsesocial.com/papers/68bb4def6d6d5674bcd01e87 https://doi.org/https://doi.org/10.1021/acs.orglett.5c03217

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

اسأل الذكاء الاصطناعي

Bookmark

View Full Paper