Figure S10 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

• Increased cxcl10 secretion was observed after repetitive stimulation of b7-h3 car t cells compared to baseline levels.
• The b7-h3 car t cells showed effectiveness against ependymomas, but their impact is limited by tumor size and immune response challenges.
• CXCL10 secretion correlates with the immune response, impacting the efficacy of b7-h3 car t cells against tumors.
• Repetitive stimulation of the car t cells enhances their secretory activity, highlighting their potential in cancer therapy.