The Moon’s unique environment, strategic position, and resource abundance make it a key target for deep space exploration. As lunar missions evolve from research to long-term habitation, leveraging local resources is essential to reduce dependence on Earth-based supply chains. Despite significant studies on the lunar environment and in-situ resource utilization (ISRU), a unified framework that integrates these findings remains lacking. This article addresses this gap by systematically reviewing and synthesizing current research to support sustainable lunar development. It first explores the use of extreme lunar environmental factors such as thermal gradients, weak magnetic fields, subsurface cavities, and geographic advantages. It then examines lunar water and mineral resource development, highlighting methods for detection, extraction, purification, and storage, alongside strategies for utilizing various minerals. The article further reviews recent progress in in-situ manufacturing, construction technologies, energy regeneration, and closed-loop life-support systems vital for lunar base establishment. These advances are crucial for creating sustainable infrastructure and maintaining life on the Moon. Finally, the paper outlines the challenges and limitations associated with ISRU and offers perspectives on future directions, aiming to inform the design of next-generation lunar missions and facilitate permanent human presence on the Moon.
Wang et al. (Wed,) studied this question.