Supplemental Table S5 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Key Points

• Cytotoxic NK cells significantly impede the response to checkpoint immunotherapy in melanoma.
• Discriminatory marker genes were identified after subclustering of macrophages, enhancing understanding of immune response.
• The study employed cluster analysis to explore macrophage markers, providing insights into immune-excluded melanoma phenotypes.
• Understanding these mechanisms may improve immunotherapeutic strategies for melanoma patients with immune exclusion.