During pre-implantation development of the mouse embryo, cells must undergo their first fate decision. While key regulators of this process are known, the variability in lineage trajectories within and between embryos during this stage of development remain poorly understood. In a new study, Avdeeva and colleagues used Bayesian modelling to understand the dynamics of key regulators YAP, SOX2 and CDX2 in this cell fate decision and characterise the variability in this system. To find out more, we spoke to co-first authors Maria Avdeeva and Madeline Chalifoux, and corresponding author Eszter Posfai, Assistant Professor at Princeton University, USA.
A Mon, study studied this question.