Palladium-catalyzed tandem cyclization reaction: access to isoxazoline-benzofuran bis-heterocycles

Key Points

• The novel reaction produces isoxazoline-bis-heterocycles with moderate to good yields.
• This approach combines β,γ-unsaturated ketoxime with gem-dihaloolefin in a tandem cyclization process.
• Palladium serves as the catalyst, demonstrating its versatility in organic synthesis.
• The method may improve synthesis strategies for complex heterocyclic compounds.