AbstractA six-week feeding trial was conducted to evaluate the efficacy of a multicomponent mycotoxin detoxifying agent (MMDA) to minimize the toxic effects of combined mycotoxins (MT) supplementation in broiler diets. A total of 1584 Vencobb day-old broiler male chicks were assigned to six dietary treatments with 12 replicates of 22 birds per floor pen. Three graded levels of MMDA (0, 1.5, and 3.0 kg/ton) and two concentrations (without and with) of MT blend (aflatoxin 100 ppb, DON 200 ppb, and T-2 1000 ppb) were supplemented to maize-soybean diet in a 3 x 2 factorial manner. On the 43rd day, carcass variables (ready-to-cook yields, relative weights of breast meat, abdominal fat) and relative weights of liver, thymus, spleen, and bursa were evaluated. Serum samples were analyzed for biochemical indices and immune responses. Liver, kidney and thigh muscle were analysed for aflatoxin B1, B2, G1, G2 and M1, T-2, HT-2, T2 Triol, T2 Tetraol, Deoxynivalenol and Deepoxy-deoxynivalenol (DOM1). The results showed that the main effects (MT and MMDA) or their interaction did not affect performance, breast meat, abdominal fat, relative weights of immune organs, and serum protein and triglyceride concentration. The inclusion of MT significantly (P<0.05) reduced the antibody titers against the ND vaccine, increased the liver weight and activities of liver function enzymes (SGOT, SGPT), and decreased the gamma-glutamyl transferase activity and serum albumin concentrations. However, the addition of MMDA to MT contaminated diet significantly reduced the concentrations of liver function enzymes. The concentrations of mycotoxins tested in the tissue were below detectable levels. Based on the results, it was concluded that the addition of broad-spectrum MMDA (at 1.5 kg/ton) to the MT-contaminated feed reduced the negative effects of MT on immune responses and liver function in broilers exposed to combined mycotoxins.
Raj et al. (Wed,) studied this question.