Morpho-Functional State of Perineum and Behavioral Changes in Rats of the Older Age Group During the Adhesion Process

Age-related changes, the use of antibiotics and chemotherapeutic agents, food with preservatives and stabilizers, physical inactivity as a physical factor, surgical interventions, inflammatory processes are the consequences of the action of various physical and chemical factors leading to changes in the structure and functioning of all components of the peritoneum with subsequent remodeling of its individual histological structures. The consequence of the restructuring of the histological structure of the intestine and peritoneum most often, according to the literature, is the development of adhesive disease. The study of the behavior of rats was carried out using the "Open Field" observation method, which allows assessing motor activity, exploratory behavior, emotionality and anxiety of animals both at the individual and species levels. The morphological study included macroscopic, histological and morphometric assessment of the peritoneal tissues of its components in rats of the older age group. A macroscopic study of the visceral and parietal peritoneum was carried out, the number of adhesions in the abdominal cavity was counted, and their thickness was measured. The detected adhesive process in rats of the older age group is characterized by gradual remodeling of the tissues of the parietal and visceral peritoneum and the formation of connective tissue neoplasms.The detected adhesions were small, mobile and elastic, but also hard and dense, localized on the surface of the peritoneal tissue. The peritoneal tissues during the adhesive process lose elasticity and mobility, thicken and compact. As a result of the formation and spread of adhesions, the mobile segments of the small and large intestine are clamped and fixed in an unnatural position, which leads to acute intestinal obstruction. The total number of adhesions in the abdominal cavity of rats of the older age group was found to be 4.03±0.15 per studied area.Their total diameter was 1.12±0.03 mm.