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This is a Literature Review study.

September 10, 2025Open Access

Targeting PI3K/AKT/mTOR signaling: A promising therapeutic approach for colorectal cancer

Key Points

Targeting the PI3K/AKT/mTOR pathway may improve treatment outcomes for colorectal cancer patients, particularly in terms of survival rates.
The review examines the impact of this signaling pathway on crucial processes like apoptosis and angiogenesis in colorectal cancer.
Latest advancements in PI3K/AKT/mTOR inhibitors provide promising options for targeted therapy against colorectal cancer.
Understanding this signaling pathway is vital for developing novel therapeutic strategies to combat colorectal cancer.

Abstract

Colorectal cancer is characterized by high prevalence, poor clinical outcomes, and unfavorable prognosis, significantly contributing to human mortality. It is well established that phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, also known as AKT)/mammalian target of rapamycin (mTOR) signaling pathway plays an important role in the pathogenesis and progression of colorectal cancer. In this review, we examine the role of the PI3K/AKT/mTOR signaling pathway in a variety of cellular processes, including proliferation, autophagy, apoptosis, angiogenesis, and epithelial-mesenchymal transformation in colorectal cancer. Furthermore, the latest advancements in the research on PI3K/AKT/mTOR inhibitors are discussed, offering new insights for targeted therapy in colorectal cancer.

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Cite This Study

Qu et al. (Thu,) studied this question.

synapsesocial.com/papers/68c1afc054b1d3bfb60e768c https://doi.org/https://doi.org/10.36922/ejmo025190175

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