Sleep difficulty is relatively common among people, and those affected often resort to short-term use of herbal supplements to ease the symptoms. This randomized, single-blind trial investigated the effects of a novel composite product, NatureU Sleep, that contains sustained-release gamma-aminobutyric acid and alpha-s1 casein hydrolysate, on sleep quality compared to the commercially available drug melatonin. The exploratory clinical trial was designed to assess the deep sleep conditions, including 17 adult participants, with the expectation that 15 would complete the trial. Utilizing wearable monitoring devices, the study evaluates the impact of the test product on deep sleep duration and proportion. The results indicated a significant increase in deep sleep duration and proportion for participants consuming sustained-release gamma aminobutyric acid and alpha-s1 casein hydrolysate, suggesting its potential as an effective sleep aid without any observed adverse events.
Luo et al. (Wed,) studied this question.