Motivation: Recently emerging two-point Dixon fat-corrected Look-Locker T1 mapping of the liver is developed as a new imaging technique that can measure the T1 value without the impact of fat. Goal(s): To evaluate how the presence of fat affects the assessment of liver fibrosis in patients with chronic liver disease using two-point Dixon fat-corrected Look-Locker T1 mapping. Approach: T1 values of liver were compared between T1 maps obtained by fat-uncorrected and fat-corrected sequences. Results: Assessment of liver fibrosis in chronic liver disease by fat-corrected T1 mapping was less influenced by the presence of fat. Impact: 2D two-point Dixon fat-corrected Look-Locker T1 mapping is essential for the proper assessment of liver fibrosis in patients with chronic liver disease under the presence of substantial hepatic steatosis.
Higashi et al. (Tue,) studied this question.