What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Quantification of Apparent Tissue Sodium Concentration (aTSC) in the Healthy Liver via 23Na and 1H MRI at 7T

Key Points

The mean tissue sodium concentration in the healthy liver was determined to be 37.0 ± 11.4 mmol/l after fasting.
Findings indicate that nutrition and calibration methods may influence tissue sodium concentration measurements.
Using 1H images for segmentation and B1+- and B1--corrected 23Na images enabled accurate quantification of tissue sodium concentration.
Essential reference data for 23Na MRI in healthy livers was provided, emphasizing the need for further investigation on various influencing factors.

Abstract

Motivation: This study seeks to enhance the appeal of using quantitative 23Na MRI in clinical settings by providing essential reference data for healthy tissue. Goal(s): The goal is to determine the mean aTSC in the healthy liver as reference for diseased livers and to identify potential methodological limitations. Approach: In this study, we determined liver aTSC in 7 healthy volunteers using 1H images for segmentation and B1+- and B1--corrected 23Na images for quantification. Results: The healthy liver's aTSC was found to be (37.0 ± 11.4) mmol/l after fasting overnight, potentially impacted by nutrition, voxel model for B1- corrections, and sodium calibration setup. Impact: This study provides essential reference data for 23Na MRI in healthy livers and also highlights the need to investigate correlations between aTSC, B1- correction, food intake, and calibration methods in healthy livers.

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Cite This Study

Lösch et al. (Tue,) studied this question.

synapsesocial.com/papers/68d4597031b076d99fa5c686 https://doi.org/https://doi.org/10.58530/2025/1732

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