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September 17, 2025

Prospective Investigation of the Value of Arterial Spin Labeling for Evaluating Bladder Cancer

Key Points

Arterial spin labeling significantly improves evaluation of bladder cancer, leveraging non-invasive techniques for better patient safety.
A moderate positive correlation exists between bladder blood flow and Ktrans values in patients with bladder cancer, highlighting promising diagnostic potential.
The approach involved ASL scans and collected data on perfusion values while comparing results based on tumor grade and muscle invasion status, enriching diagnostic variability.
This method may enable more accessible and effective evaluations of bladder cancer, reducing reliance on contrast agents that can pose risks to patients.

Abstract

Motivation: Current bladder cancer (BCa) evaluation techniques require contrast agent, which is contraindicated in some patients. Goal(s): We aimed to assess the potential value of arterial spin labeling (ASL) for evaluating BCa. Approach: We conducted ASL scans of patients with BCa and obtained corresponding perfusion values (bladder blood flow BBF) of the bladder lesions. We collected pathological and immunohistochemical information, dynamic contrast-enhanced quantitative parameters, and Ktrans values. Results: BBF and Ktrans were moderately positively correlated. BBF values for high-grade urothelial carcinoma, muscle invasion and Ki-67 >25% were higher than those for low-grade urothelial carcinoma, non-muscle invasion and Ki-67 ≤25% (P<0.05). Impact: Non-invasive and quantitative arterial spin labeling is a valuable technique for evaluating bladder cancer because it enables quantifying tumor perfusion and offers insights into the physiological and pathological processes.

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Cite This Study

Guo et al. (Tue,) studied this question.

synapsesocial.com/papers/68d4597b31b076d99fa5cb44 https://doi.org/https://doi.org/10.58530/2025/1073

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