What type of study is this?

This is a Quantitative Study study (also classified as: Animal Study).

September 17, 2025

Pathological changes in brain networks in P301S tau transgenic mouse model

Key Points

The PS19 mouse model shows notable decreases in neuronal function within critical brain regions, indicating tauopathy's impact.
Significant reduction in fiber orientation distribution was observed in the entorhinal and perirhinal cortices at 3 months.
Awake functional MRI and diffusion MRI were utilized to evaluate brain network alterations in tauopathy mice.
Establishing tauopathy imaging via MRI may enhance early detection and understanding of tau-related neurodegenerative diseases.

Abstract

Motivation: Visualization of pathological changes in tauopathy is expected to elucidate its detailed clinical symptoms. Goal(s): Our goal was to assess the pathological changes in a tauopathy mouse model by measuring brain function and structural networks. Approach: Wild-type and tauopathy mouse models (PS19) aged 3, 6, and 9 months were evaluated using awake functional MRI. After perfusion fixation, ex vivo brain were measured using diffusion MRI. Results: The PS19 mice exhibited decreased neuronal function in the amygdala, hippocampus, entorhinal and perirhinal cortices. Three -month-old PS19 mice showed a significant decrease in fiber orientation distribution in the entorhinal and perirhinal cortices. Impact: The establishment of tauopathy imaging using MRI could lead to the early and non-invasive detection of tau-related diseases, such as Alzheimer's disease.

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