Stereoselective synthesis of P-stereogenic nucleotide prodrugs and oligonucleotides | Synapse
September 19, 2025
Stereoselective synthesis of P-stereogenic nucleotide prodrugs and oligonucleotides
Key Points
Recent advances in stereoselective synthesis enhance the development of new nucleotide prodrugs and oligonucleotides.
The review discusses both chemical strategies and enzymatic approaches, indicating a diversified methodology in synthesis.
By focusing on P-stereogenic compounds, this synthesis promises improved efficacy in therapeutic applications.
These advancements could lead to significant breakthroughs in pharmaceutical development, highlighting the potential for innovative treatments.
Abstract
This review highlights recent advances in stereoselective synthesis of P-stereogenic nucleotide prodrugs and oligonucleotides, covering both chemical and enzymatic strategies.