Abstract: Autoimmune diseases arise from impaired immune responses, leading to chronic inflammation and progressive tissue damage. Conventional therapies are effective in managing symptoms and reducing pain; however, they are often associated with various adverse effects. In contrast, nutraceuticals derived from natural bioactive compounds offer promising therapeutic potential because of their immunomodulatory and anti-inflammatory properties. Key nutraceuticals, including polyphenols (such as curcumin and resveratrol), omega-3 fatty acids, flavonoids, probiotics, and essential vitamins (vitamin D, E, and C), have demonstrated efficacy in regulating immune responses and alleviating symptoms in autoimmune diseases, such as inflammatory bowel disease, cardiovascular diseases, psoriasis, and diabetes. These compounds exert beneficial effects by modulating inflammatory cytokines, reducing oxidative stress, and restoring immune homeostasis. Several animal studies and human trials have demonstrated the effectiveness of nutraceuticals, either as monotherapy or adjuncts to conventional treatments, in reducing disease progression and improving patient outcomes. Integrating nutraceuticals with modern therapies offers a promising way to autoimmune disease management, potentially reducing dependency on pharmacological treatments. This review provides a concise overview of nutraceuticals, including their classification and therapeutic applications across various disease conditions such as inflammatory bowel disease, cardiovascular diseases, psoriasis, diabetes mellitus, ulcerative colitis, and Crohn’s disease. Furthermore, it highlights recent clinical trials evaluating the efficacy of nutraceuticals, particularly in the management of diabetes, ulcerative colitis, and Crohn’s, underscoring their potential role in integrative healthcare strategies.
Kapil et al. (Mon,) studied this question.