September 20, 2025Open Access

EUS-guided gallbladder drainage versus percutaneous gallbladder drainage in high-risk patients with acute cholecystitis: a propensity score-matched analysis

Key Points

EUS-guided gallbladder drainage achieved clinical success in 93% of patients compared to 80% for percutaneous drainage, indicating better outcomes.
Technical success rates were high for both procedures, with 96% success for EUS-guided drainage versus 98% for percutaneous drainage, showing equivalence.
Patients undergoing percutaneous drainage had significantly more complications (44%) compared to those with EUS-guided drainage (16%), emphasizing safety differences.
The study highlights EUS-guided drainage as a preferable method for patients with acute cholecystitis who cannot have surgery, given lower complication rates.

Abstract

Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) using lumen apposing metal stent (LAMS) has emerged as a treatment option in patients with acute cholecystitis (AC) deemed unfit for surgery. Prior to this technique, percutaneous transhepatic gallbladder drainage (PT-GBD) was the only drainage modality available for these patients. This study compares clinical outcomes of EUS-GBD versus PT-GBD in high-risk surgical patients with AC. From July 2019 to October 2023, all consecutive patients with AC undergoing EUS-GBD (using LAMS) and PT-GBD at a single academic medical center were retrospectively reviewed and analyzed. A propensity score-matched analysis using age, sex, and Charlson Comorbidity Index was performed. This was used to obtain a 1:1 ratio of PT-GBD:EUS-GBD patients. Technical success was defined as successful placement of LAMS or percutaneous cholecystostomy tube in the gallbladder. Clinical success was defined as resolution of patients' symptoms and normalization of white cell count within 96 h post procedure without recurrence of AC. Outcomes were analyzed using Fisher's exact test and Student's t test. Following propensity score matching, 57 EUS-GBD patients were matched with 57 PT-GBD patients. Technical success was seen in 96% (55/57) in the EUS-GBD group and 98% (56/57) in the PT-GBD group (p > 0.99). Clinical success was observed in 93% (52/56) in EUS-GBD group and 80% (45/56) in PT-GBD group (p = 0.093). PT-GBD patients underwent more procedures than the EUS-GBD group (median 3 vs 2, p < 0.0001) and had more complications (44% vs 16%, p = 0.0010). The median survival was 573 days for EUS-GBD and 452 days for PT-GBD (p = 0.77). EUS-GBD is superior to PT-GBD, requiring fewer gallbladder-related procedures and lower rates of adverse events. Given these benefits, it has emerged as the preferred non-surgical alternative in the management of patients with AC who are poor surgical candidates.

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Cite This Study

Pawa et al. (Mon,) studied this question.

synapsesocial.com/papers/68d46fcd31b076d99fa69e6f https://doi.org/https://doi.org/10.1177/17562848251375376

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