With the use of cyclization and Schiff's base reactions, a new group of 1,2,4-triazole-linked quinoline derivatives (3a – 3j) was effectively synthesized with yields ranging from moderate to excellent. The potential anticancer, antibacterial, and anthelmintic medicinal properties of these compounds were subsequently studied through molecular docking studies. The MTT analysis method was employed to evaluate anticancer activity, and the most efficient derivatives were compounds I-3b, I-3f, and I-3j, with IC50 values of 23.46±0.001, 20.02±0.013, and 25.76±0.016µg/mL exhibiting good activity, according to the data. In comparison to streptomycin, antibacterial studies against both Gram-positive and Gram-negative bacteria showed significant actions. Furthermore, they showed anthelmintic properties when tested against albendazole. Molecular docking research revealed that the binding energies of all of the substances ranged from -9.1 to -10.8 Kcal/mol.
Sreelatha et al. (Wed,) studied this question.