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Background While several studies have noted a higher SII correlates with multiple diseases, research on the association between SII and cataract remains limited. Our cross-sectional study seeks to examine the association between SII and cataract among outpatient US adults. Methods This compensatory cross-sectional study utilized NHANES data from 1999 to 2008 cycles, conducting sample-weighted multivariate logistic regression and stratified analysis of subgroups. Results Among 11,205 adults included in this study (5,571 46.2% male; 5,634 53.8% female), 2,131 (15.2%) had cataract and 9,074 (84.8%) did not have cataract. A fully adjusted model showed that SII higher than 500 × 10 9 /L was positively correlated with an increased risk of cataracts among women (OR, 1.27; 95% CI, 1.02–1.59) ( p = 0.036). However, no difference was found in the men subgroup, and there was no significant interaction between SII and sex. Conclusion Our results indicated that a SII higher than 500 × 10 9 /L was positively correlated with an increased risk of cataracts in women. This study is the first to specifically investigate the impact of a high SII on cataract risk in outpatient adults in the United States. By effectively addressing inflammation, it is possible to mitigate cataract progression and significantly enhance patient outcomes.
Huang et al. (Wed,) studied this question.