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Electrospinning stands out as a highly precise method for producing nanofibers, offering exceptional control over their morphology by adjusting parameters, making it the preferred choice for efficiently tailoring nanofiber properties. Nanofibers, increasingly recognized for the possibilities within drug delivery systems that they possess, offer distinctive features such as high surface area (10 to 1000m2/g), efficient drug loading, and the ability to provide sustained drug release. Fabricating nanofibers from biopolymers is particularly favored due to numerous advantages including biocompatibility, capacity to replicate extracellular matrix, biodegradability, non-cytotoxicity, and renewability, making them a preferred option over other polymers for various applications. In this regard, this review thoroughly emphasizes drug-loaded electrospun biopolymers for diverse applications including, wound healing, pesticide release matrices, stent coatings, and therapeutic applications. It also discusses recent progress in drug incorporation into nanofiber fabrication methods, assessment of drug loading and release, and various drug release kinetics. This review provides insight about molecular interactions with the help of molecular dynamics providing valuable insights as they can elucidate the behavior of molecules over time, allowing researchers to investigate drug release dynamics, the stability of drug carriers, and interactions between drugs and their targets at the molecular level for the engineering of next-generation drug delivery systems.
Shastri et al. (Fri,) studied this question.