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A wide spectrum of progressive neurological disorders with a multifactorial etiology that contributes to the pathophysiology of the disease are collectively referred to as nervous system disorders (NSDs). A number of molecular and cellular processes, including oxidative stress, mitochondrial malfunction, protein misfolding, excitotoxicity, and inflammation, are involved in this intricate process. One current method of studying the degenerative process of the disease is to investigate the role of genes, as genetic forms of degenerative diseases are rather uncommon. Thus, it has been hypothesized that close interactions between genetic and environmental factors are responsible for idiopathic forms of the diseases; the genetic component may favor or even protect against the disease process. Owing to their wide range of biological and pharmacological activities, natural compounds may be suitable options for the treatment of these complex morbidities. Nevertheless, their low bioavailability and consequently inadequate brain delivery have limited their therapeutic potential against neurodegenerative diseases. An overview of the molecular mechanisms underlying the neuroprotective effects of natural compounds is given in this article.
Pratap et al. (Fri,) studied this question.