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DTI of peripheral nerves for detecting nerve damage has been very challenging due to limited resolution and imaging artifacts of the conventional single-shot diffusion-weighted echoplanar imaging (SS-DW-EPI). Here, we have evaluated the feasibility of improved DTI with multi-shot DW-EPI (MUSE) by comparing mean diffusivity (MD) and fractional anisotropy (FA) estimates of tibial and peroneal nerves with those from SS-DW-EPI in ten healthy subjects. MUSE showed lower within-subject coefficient of variation in diffusion estimates, indicating improved repeatability, while correlation analysis showed noticeable differences between FA estimates. Our results show the feasibility of MUSE for in vivo evaluation of peripheral nerves.
Yoon et al. (Wed,) studied this question.