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Recent studies have suggested that the increase in blood-brain barrier (BBB) permeability is associated with both aging and the progression of the Alzheimer’s disease (AD). However, the association of the amyloid pathology with the increased BBB leakage at different disease progression is still poorly understood. In this study, we performed a cross-sectional study to investigate the BBB permeability changes in AD transgenic mice with aging. We also propose the network-aided analysis allows the scan time reduction without compromising the accuracy of the detection of the subtle permeability
Bae et al. (Wed,) studied this question.