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Impaired cerebral waste clearance occurs in healthy ageing and various neurodegenerative diseases and is theorized to be due to compromised arterial pulsatility. Profiting from high-resolution 7 Tesla MRI, the current study investigated the association between pulsatility characteristics of a small artery in the basal ganglia (BG) with interstitial fluid (ISF) characteristics of the BG - as derived with intravoxel incoherent motion. This study found that an increased small vessel velocity pulsatility was related to higher ISF-diffusivity in the BG of an elderly sample. This increased ISF-diffusivity might represent increased perivascular fluid diffusivity, influencing the waste fluid transport out of these spaces.
Thiel et al. (Wed,) studied this question.