QRAGE - Multi-Echo MPnRAGE and Model-Based Reconstruction for Quantitative MRI of Water Content, T1, T2* and Magnetic Susceptibility at 7T

The development of fast, accurate, and robust methods for multiparametric quantitative MRI (qMRI) at ultrahigh field strength remains an important topic of research. Here, we present a novel qMRI technique for the simultaneous quantification of water content, T1, T2*, and magnetic susceptibility, termed QRAGE. The proposed method combines a highly undersampled multi-echo MPnRAGE sequence with a model-based reconstruction approach. It acquires 171 different contrasts with full brain coverage and 1 mm isotropic resolution within 7:20 min from which the parametric maps are estimated. The accuracy and precision of QRAGE are demonstrated by comparison to gold-standard reference methods.