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Alzheimer’s Disease (AD) is characterized by increased inflammation and increased glucose utilization as detected by FDG-PET. Using a new deuterium MRI method based on a D7glucose tracer, we can image the brain of a mouse model of AD with in plane resolution approaching 1 mm. Mass spectrometry imaging of the same brains shows characteristic changes in protein associated glycans that correlate well with immunohistochemical staining for inflammation. We believe this new research pipeline can provide powerful new insights into AD pathophysiology.
Merritt et al. (Wed,) studied this question.
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