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Direct access to myelin content through the detection of signals from the myelin lipid-protein bilayer can be achieved using advanced short-T2 techniques. Here, we translate an existing procedure for mapping the myelin bilayer ex vivo to in vivo human application. Myelin maps are generated by fitting a three-component complex model to multi-TE (20–800µs) data acquired using the HYFI variant of the zero-TE sequence. The presented myelin maps exhibit expected white/grey matter contrast and are of reasonable quality. The step to in vivo represents an important advancement for myelin bilayer mapping as a promising emerging technique.
Baadsvik et al. (Wed,) studied this question.