August 14, 2024

Reliable Glutamate Measurements at 3T: Which Sequence should I Choose?

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Abstract

This meta-analysis discusses the intra- and inter-subject variability of glutamate measurements in MRS, comparing widely used sequences on clinical scanners (PRESS, sLASER, MEGA-PRESS, MEGA-sLASER, HERMES). To minimize variance in glutamate measurements, the authors recommend sLASER over PRESS, non-edited over edited MRS, and OFF over DIFF spectra.

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Cite This Study

Durham et al. (Wed,) studied this question.

synapsesocial.com/papers/68e5c61db6db64358755c4cb https://doi.org/https://doi.org/10.58530/2023/5264

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A robust MRSI protocol to investigate glutamatergic mechanisms in glioma2024
2Double-DANTE-PRESS: a multi-metabolite-selective 1H-MRS sequence for human brain measurements of glutamate and glutathione at 7T2025
3In vivo Glx measurements from GABA-edited HERMES at 3T are not consistent with those from short-TE PRESS across scanners, regions, and age groups.2025
4In Vivo Glx Measurements From GABA‐Edited HERMES at 3 T Are Not Consistent With Those From Short‐TE PRESS Across Scanners, Brain Regions, Diagnostic and Age Groups2025 · 1 citations
5Magnetic Resonance Fingerprinting for Glutamate Quantification: Towards the Intermediate Exchange Regime2025

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