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Using IVIM imaging for completely non-invasive perfusion MRI is gaining popularity. IVIM perfusion assessment depends not only on capillary network characteristics, but also on diffusion encoding-time. In this study, a flow-compensated pulse sequence with variable encoding-time was implemented and validated through phantom measurements, and subsequently used to study the encoding-time dependence of IVIM perfusion fraction in human brain tissue. Initial findings indicate a decrease in perfusion fraction as encoding-time increases.
Rosenqvist et al. (Wed,) studied this question.