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Kidney transplantation is the preferred treatment for end-stage kidney disease. Donor kidney viability is currently assessed using donor age, medical history, and serum creatinine, but these have limited predictive power. As part of a study to determine if MRI can be used as an alternative, more accurate, measurement of donor kidney viability, we outline a multiparametric MRI protocol (high resolution structural scans, relaxometry (T1, T2 and T2*) mapping, susceptibility-weighted-imaging (SWI), diffusion-weighted imaging (DWI), and magnetisation transfer ratio (MTR)) to study human whole kidneys that have been declined as transplants. MRI measures will be integrated with 3D-histology and tissue proteomics datasets.
Daniel et al. (Wed,) studied this question.
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