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Here we present a method based on spectrally selective saturation recovery 1H spectroscopy to measure the apparent T1 values of NAD+ in the downfield at 7T for the first time. With spectrally selective saturation and excitation, NAD+ exhibits enhanced T1 recovery do to cross relaxation with water, and we report values in three subjects between 200 and 300 ms. Measuring apparent T1 is crucial as a correction factor for quantitative spectroscopy of NAD+.
Wilson et al. (Wed,) studied this question.