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Parkinson’s disease is a chronic and progressive neurodegenerative disorder that primarily affects motor function. Although modern treatments can relieve and help patients manage symptoms, there is still an urgent need for innovative new therapies that can slow down the disease’s severity progression. This review examines numerous innovative and promising experimental treatments for Parkinson’s disease that are either in development or clinical trial. It will review the potential L-Dopa therapy – namely using a dopamine replacement agent during the treatment of the Parkinson’s disease to manage the symptoms of patients. Additionally, the review also covers developing neuromodulation techniques, including deep brain stimulation, which attempts to modulate brain activity as a way of alleviating Parkinson’s symptoms. The review evaluates the current status in treatment for each experimental approach, summarizing their suggested mechanisms of treatment, preclinical discoveries, and clinical trials. It also discusses the main challenges and obstacles in relation to these therapies. In conclusion, while significant barriers and limitations remain, the review highlights the progress made in the development of newer potential treatments that may improve conditions for patients living with Parkinson’s disease.
Jintian Du (Wed,) studied this question.