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Amoxicillin/clavulanic acid is a combination penicillin-type antibiotic used to treat a wide variety of bacterial infections. However, there are many Amoxicillin- clavulanic Acid brands marketed in Libya, with different quality and prices. The study was aimed to evaluate the quality of five commercial Amoxicillin- clavulanic Acid (625mg) products available in the Libyan market. This study was conducted to assess quality, all products were examined visually for their organoleptic properties, weight uniformity test, friability, hardness, disintegration test, dissolution test and IR were assayed. We carried out a physical comparison of all Amlodipine tablet products and assessed their quality. All the tested five brands were equivalent and complying with the official tests for weight variation, friability, disintegration and Hardness tests according to USP specifications. The friability test between 0.054% to 0.223%. All formulations were disintegrated between 1.57 to 9.04 minutes. Infra-Red (IR) spectroscopic investigations were revealed no any difference between brands and showed identical peaks compared to the reference. All the available brands in local Libyan pharmacies are having, with in the specified quality range and considerably, can be chosen according to good quality and cost, to improve the therapeutic benefit and patient compliance without interchangeability.
Abdulrhman Ahmed Akasha (Fri,) studied this question.
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