A comparison of myopia control in children with orthokeratology, defocus-incorporated multiple segment lenses (DIMS) spectacles, Defocus Incorporated Soft Contact (DISK) lenses, and single-vision spectacles for 12 months

Abstract PURPOSE: To evaluate the efficacy of orthokeratology, defocus-incorporated multiple segment lenses (DIMS) spectacles, defocus incorporated soft contact (DISK) lens, and single-vision spectacles (SVS) on myopia control over 12 months in one clinical center. METHODS: The study was a non-randomized experimenter-masked prospective controlled study of individuals aged 8~12 years with progressing myopia but no ocular pathology. Participants were allocated, according to patients/parents’ choice, to receive DIMS (Hoya® MiyoSmart®) spectacles, DISK (Defocus Incorporated Soft Contact) lenses, orthokeratology or SVS (control group). The key outcome variables, axial length (AL) and cycloplegic spherical equivalent refraction (SER) were measured at baseline and after 3, 6, 9and 12 months. RESULTS: Among the 103 children who were eligible, 90 (87.39%) children attended the baseline examination and 70 (77.78%) were analyzed (SVS: n = 14; DIMS: n = 13; DISC: n = 20; Orthokeratology: n = 25). At the 12- month mark, the mean changes in AL were 0.49 ± 0.20 mm, 0.25 ± 0.11 mm, 0.19 ± 0.26 mm and 0.21 ± 0.20 mm in SVS, DIMS, DISC and Orthokeratology group, respectively (P = 0.001, ANOVA); And the mean changes in SER after the same 12 months were −1.00 ± 0.33D, −0.36 ± 0.62D, and −0.37 ± 0.48D (p CONCLUSIONS: DISC, orthokeratology, DIMS had similar efficacy of myopia control in children. Registered Code:MR-33-22-012252