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Skin ageing is a multifaceted process influenced by both intrinsic and extrinsic factors.The mechanisms underlying skin ageing, focus on molecular pathways such as oxidative stress, inflammation, and photoaging.This review explores the flourishing field of herbal interventions in the treatment of ageing, exploring the potential of various plant-based remedies in promoting longevity and maintaining youthful vitality.The free radical theory of ageing suggests that the accumulation of reactive oxygen species (ROS) leads to cellular damage, contributing to skin ageing.Mitochondrial dysfunction and DNA damage further exacerbate this process, resulting in reduced collagen synthesis and increased matrix metallopeptidase (MMP) expression, leading to skin laxity and wrinkles.Inflammation also plays a pivotal role in skin ageing, with proinflammatory cytokines inducing cellular senescence and collagen degradation.Chronic exposure to ultraviolet (UV) radiation accelerates skin ageing through direct DNA damage and collagen breakdown.Various antiageing strategies are discussed, including the use of antioxidants to neutralize oxidative stress, inflammation, photoaging and promoting collagen synthesis.The botanicals discussed possess antioxidant, anti-inflammatory, and collagen-stimulating properties making them valuable ingredients in antiageing skincare formulations.Understanding the molecular mechanisms of skin ageing and exploring natural remedies can pave the way for innovative skincare interventions targeting age-related changes in the skin.
Kumari et al. (Mon,) studied this question.