Assessment of the Toxicity Effects of Inhalation Exposure to Kerosene and Naphtha Fumes on some Liver and Kidney Parameters in Rats

Abstract Exposure to petroleum compounds and vapours has been shown to have harmful effects on many different organs and systems of the body, especially the liver. This study aimed to evaluate the effects of kerosene the rats were separated into four groups, each with five rats: three for testing and one for control. Using an altered nose-inhalation exposure approach, rats were exposed to kerosene vapours for six hours daily for 15, 30 and 45 days. The study measured the parameters of blood in rats after they were sacrificed. The study revealed a significant rise (P≥0.01) in the levels of serum aspartate aminotransferase (A.S.T.), alkaline phosphatase (A.L.P.), and alanine aminotransferase catalase (A.L.T.) in rats exposed to kerosene and naphtha fumes for 15, 30, and 45 days, as compared to the control group. The findings also indicated a statistically significant (P≥0.01) increase in the serum bilirubin levels of rats exposed to kerosene and naphtha fumes for 15, 30, and 45 days compared to the control group. The findings demonstrated a statistically significant increase (p≥0.05) in serum creatinine and serum urea levels in rats exposed to kerosene and naphtha fumes for 25, 30, and 45 days compared to the control group. Additionally, the study demonstrated a significant increase (p≥0.05) in serum creatinine levels in rats exposed to kerosene fumes for 45 days compared to rats exposed for 15 and 30 days. It may be concluded that the liver parameters were negatively impacted by inhaling fumes containing Kerosene and naphtha.