Research on the correlation between rash and complement C3, C4 levels and the occurrence and development of lupus nephritis

Abstract Objective We here investigate the relationship between the appearance of skin rash, complement, and the risk of systemic lupus erythematosus and lupus nephritis. Methods All data were collected from 71 patients with SLE (without LN) and 200 patients with LN treated at our hospital from August 2018 to August 2023. The latter group was further categorized into a high eGFR group (eGFR ≥ 60 ml/min; 100 cases) and a low eGFR group (eGFR 0.05. SLEDAI scores remained statistically insignificant, possibly due to treatment-induced differences. Conclusion The absence of skin rash and low levels of complement C3 are risk factors for the occurrence of LN, and their combined predictive diagnostic value is higher. Disease activity may not necessarily be the sole factor for further deterioration of kidney function.