Interpregnancy Interval After Healthy Live Birth and Subsequent Spontaneous Abortion

Importance Many studies have reported that the interpregnancy interval (IPI) is a potential modifiable risk factor for adverse perinatal outcomes. However, the association between IPI after live birth and subsequent spontaneous abortion (SA) is unclear. Objective To investigate the association of IPI after a healthy live birth and subsequent SA. Design, Setting, and Participants This prospective cohort study used data from 180 921 women aged 20 to 49 years who had a single healthy live birth and planned for another pregnancy and who participated in the Chinese National Free Prepregnancy Checkups Project from January 1, 2010, to December 31, 2020. Statistical analysis was conducted from June 20 to October 5, 2023. Exposure Interpregnancy interval, defined as the interval between the delivery date and conception of the subsequent pregnancy, was categorized as follows: less than 18 months, 18 to 23 months, 24 to 35 months, 36 to 59 months, and 60 months or longer. Main Outcomes and Measures The main outcome was SA. Multivariable-adjusted odds ratios (ORs) were calculated by logistic regression models to examine the association between IPI and the risk of SA. Dose-response associations were evaluated by restricted cubic splines. Results The analyses included 180 921 multiparous women (mean SD age at current pregnancy, 26.3 2.8 years); 4380 SA events (2.4% of all participants) were recorded. A J-shaped association between IPI levels and SA was identified. In the fully adjusted model, compared with IPIs of 18 to 23 months, both short (lt;18 months) and long (≥36 months) IPIs showed an increased risk of SA (IPIs of lt;18 months: OR, 1.15 95% CI, 1.04-1.27; IPIs of 36-59 months: OR, 1.28 95% CI, 1.15-1.43; IPIs of ≥60 months: OR, 2.13 95% CI, 1.78-2.56). Results of the subgroup analysis by mode of previous delivery were consistent with the main analysis. Conclusions and Relevance This cohort study of multiparous women suggests that an IPI of shorter than 18 months or an IPI of 36 months or longer after a healthy live birth was associated with an increased risk of subsequent SA. The findings are valuable to make a rational prepregnancy plan and may facilitate the prevention of SA and improvement in neonatal outcomes.