1388-P: Risk of Diabetes among Children and Young Adults after COVID-19 Infection—The DiCAYA Study

Introduction 18) and young adults (18-44) post COVID-19 infection. Methods: Pooled fixed-effects meta-analyses were performed. Patients (n=5,412,604) with no evidence of diabetes who received care in 2018-2019 were followed through diabetes diagnosis, death, or end of follow-up (12/31/22). COVID-19 infection was defined using labs or diagnoses from 6/1/20-12/31/21. Person-time was calculated from infection date for cases or a randomly selected visit date for controls. Propensity score-weighted Cox regression models were run at each site individually to estimate hazard ratios (HR) for diabetes risk for children and young adults. Results: COVID-exposed individuals were at higher risk of incident diabetes compared to those with no documented infection (Children HR = 1.85 1.69, 2.03; Young Adult HR = 1.37 1.31, 1.42). All participating sites reported elevated risk but results were more heterogeneous across young adults (range 1.3-3.7, heterogeneity I2=94% vs. range 1.6-2.0, I2=0%, Figure 1). Conclusion: These preliminary findings suggest COVID-19 infection is associated with increased risk of incident diabetes among children and young adults. Disclosure S. Conderino: None. H. Kirchner: None. L. Thorpe: None. J. Divers: None. A.G. Hirsch: None. C.M. Nordberg: None. B.S. Schwartz: None. B. Cai: None. C. Rudisill: None. J.S. Obeid: None. A.D. Liese: None. B.E. Dixon: Other Relationship; Elsevier. D. Dabelea: None. A. Bellatorre: None. H. Shao: Consultant; Eli Lilly and Company. J. Bian: None. Y. Guo: None. K. Reynolds: Research Support; Merck Sharp Merck & Co., Inc. M.K. Kamboj: None. E.A. Mendonca: None. K. Allen: None. S. Burgett: None. E. Lustigova: None. S. Bost: None. M. Maltenfort: None. L.H. Utidjian: None. M.M. Zhou: None. T.L. Crume: None. A. Titus: None.