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Every human being experiences pain such as during chronic pain, infection, surgery or other medical interventions. In overcoming pain in patients, it is necessary to administer drugs in the form of analgesics. One of the herbal plants that can be used is Moringa leaves (Moringa oleifera Lamk) which contains metabolite compounds such as flavonoids, alkaloids, steroids and tannins that have analgesic activity. The aim of this research is to assess the analgesic activity of Moringa leaf extract (Moringa oleifera Lamk) in mice (Mus musculus) using 96% ethanol solvent and writhing reflex method. The experimental animals were divided into 3 groups: negative control group (Na-CMC 0.5%), positive control group (aspirin) and treatment group (Moringa leaf extract). The treatment material is given orally. Animals were treated with 0.6% acetic acid injection intraperitoneally to give the effect of pain in mice. Measurement of the analgesic effect with the writhing reflex method is seen from the number of writhing. Based on the results of the study it can be concluded that the administration of Moringa leaf extract (Moringa oleifera Lamk) with the writhing reflex method has analgesic activity, which can reduce the pain response characterized by a decrease in the number of writhing in mice (Mus musculus).
Yuwono et al. (Sat,) studied this question.