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The paper presents the results on the risk criteria for disruption of adaptive restructuring and the development of cardiovascular disasters in residents of the European North and the Arctic of the Russian Federation. 980 people aged 21 to 55 years were examined, including 191 people living in the Arctic, beyond the Arctic Circle (the villages of Revda and Lovozero of the Murmansk region). The comparison group included 789 people of the specified age range living in the Arkhangelsk region. It has been established that the risk of disruption of adaptive rearrangements in Arctic residents is due to the absence of a compensatory reaction to normalize lipid metabolism with a deficiency in the content of HDL, ApoA-I ligand, the accumulation of metabolic products: cholesterol, triglycerides, LDL occurs with an increase in cytotoxic activity of lymphocytes, production of pro-inflammatory cytokines and is associated with the risk of cardiovascular disasters in Arctic residents of the Russian Federation.
Pashinskaya et al. (Wed,) studied this question.