FIGURE 3 from Humanized Patient-derived Xenograft Models of Disseminated Ovarian Cancer Recapitulate Key Aspects of the Tumor Immune Environment within the Peritoneal Cavity

Analysis of human cytokine levels in huPDX and non-huPDX models indicates their origin. A–C, Examples of the subtypes of cytokines in huPDX. A, PDX-intrinsic cytokines. B, Immune cell–dependent cytokines. C, Immune cell–influenced cytokines. D–F, Tables of cytokine levels in ascites fluid. Levels are presented as the natural log of the least squares means (non-huPDX n = 7, huPDX n = 7) D. PDX-intrinsic cytokines (levels >1 in non-huPDX). Factors with detectable levels in only one or two PDX models are listed separately. E, Immune cell–dependent cytokines with non-huPDX levels F, Factors with detectable levels in the non-huPDX, but significantly increased levels in the huPDX.