Structured Exercise Improves Fatigue and Health-Related Quality of Life in Metastatic Breast Cancer Patients: The Multinational Randomized Controlled Preferable-Effect Study

INTRODUCTION -0.6], p=.027, ES=0.22) and improvement in HRQoL (+4.8 2.2; 7.4, p=.0003, ES=0.33) compared to UC at 6 months (primary endpoint), as well as at 3 and 9 months. EX also improved physical fitness (+24.3 Watts, 15.5; 33.1, ES=0.42, at 6 months) and numerous relevant QLQ-C30 scales, including social functioning, pain, and dyspnoea. CONCLUSION This large multinational study demonstrates that supervised exercise improves fatigue, HRQoL, and other clinically relevant outcomes in patients with mBC. Based on these findings, supervised exercise should be recommended to patients with mBC.