Mp46-01 Pathogen Species Are the Risk Factors for Postoperative Infection of Patients With Transurethral Resection of the Prostate: A Retrospective Study

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Surgical Therapy & New Technology III (MP46)1 May 2024MP46-01 PATHOGEN SPECIES ARE THE RISK FACTORS FOR POSTOPERATIVE INFECTION OF PATIENTS WITH TRANSURETHRAL RESECTION OF THE PROSTATE: A RETROSPECTIVE STUDY Jiexiang Lin, Zesong Yang, Haishou Fu, and Liefu Ye Jiexiang LinJiexiang Lin , Zesong YangZesong Yang , Haishou FuHaishou Fu , and Liefu YeLiefu Ye View All Author Informationhttps://doi.org/10.1097/01.JU.0001008668.53858.38.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Transurethral resection of the prostate (TURP) is a widely used surgical procedure for benign prostatic hyperplasia (BPH), with an infection rate of 2.6% to 13.5%. This study aimed to analyze the infection risk factors with TURP treatment and establish a predictive model to help clinicians make personalized treatment plans. METHODS: Our study was designed one-center and retrospectively enrolled 1169 BPH patients. Demographics and clinical parameters were retrospectively analyzed. Univariate and multivariate analyses were used to identify risk factors for postoperative infection. Then, a risk model with infection prediction values was created. Calibration curves, ROC curves, and decision curve analysis (DCA) evaluate its prediction consistency, discrimination ability, and clinical net benefit. RESULTS: 235 out of 1169 (20.10%) patients had positive urine cultures pre-surgery. Operation time, preoperative indwelling urinary catheter (PIUC), and urine culture were independent risk factors (all p<0.05). Interestingly, pathogens species in pre-surgery urine (PEnterococcusfaecium=0.014, PPseudomonas aeruginosa=0.086) were also independent risk factors. Patients with positive Enterococcus faecium (37.50%) were most likely to have postoperative infections, followed by Klebsiella pneumonia (29.41%) and Pseudomonas aeruginosa (25.81%). The model based on pathogens species had an AUC of 0.705 (95% CI: 0.650-0.760). The calibration curve and DCA exhibited good prediction consistency and clinical practicability. CONCLUSIONS: To our knowledge, our study is the first to use pathogen species in urine before surgery as risk factors for infection prediction after TURP. our nomogram has an essential role in predicting patients' postoperative infections and in better postoperative antibiotic decision-making. Download PPT Source of Funding: This work was supported by the Natural Science Foundation of Fujian Province (Grant number 2021J01398) © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e752 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Jiexiang Lin More articles by this author Zesong Yang More articles by this author Haishou Fu More articles by this author Liefu Ye More articles by this author Expand All Advertisement PDF downloadLoading ...