Mp75-16 Risk of Urinary Tract Infection in Anti-Androgen Medication Users? A Claims Database Perspective

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Non-neurogenic Voiding Dysfunction (Excluding OAB) (MP75)1 May 2024MP75-16 RISK OF URINARY TRACT INFECTION IN ANTI-ANDROGEN MEDICATION USERS? A CLAIMS DATABASE PERSPECTIVE Pranjal Agrawal, Taylor P. Kohn, Rachel S. Rubin, Marisa Clifton, and Maria Uloko Pranjal AgrawalPranjal Agrawal , Taylor P. KohnTaylor P. Kohn , Rachel S. RubinRachel S. Rubin , Marisa CliftonMarisa Clifton , and Maria UlokoMaria Uloko View All Author Informationhttps://doi.org/10.1097/01.JU.0001008676.21744.5f.16AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Urinary tract infections (UTIs) are common in women. Antibiotics are standard treatment; but many women treated with antibiotics have symptom recurrence. Recent research has shown androgen receptors in the vestibule 229412 females had 5-7 Rx; 143259 had 8-10 Rx; UTI 10.7% vs 8.8% RR 1.2 (1.2-1.2); Dyspareunia 0.8% vs 0.6% RR 1.2 (1.1-1.2); Vulvodynia 0.1% vs 0.1% RR 1.4 (1.3-1.6), Pelvic floor dysfunction 0.5% vs 0.4% RR 1.1 (1.1-1.2)). Risk of rUTI was also sig. higher in those with anti-androgen Rx compared to controls (6.9% vs 5.6%, Chi-Square p<0.01). Compared to control, propensity-score matched groups of those with 5-7, 8-10, or ≥11 Rx had sig. higher RR of all outcomes (Figure 2). Compared to those with 5-7 Rx, propensity-score matched groups of 8-10, or ≥11 Rx had sig. lower RR of all outcomes. CONCLUSIONS: Anti-androgen medication Rx raises the risk of UTI, dyspareunia, vulvodynia, &/or pelvic floor dysfunction, but the clinical significance of this association is still a matter of debate. It is worth noting that the risk is particularly elevated during the initiation of medication, underscoring the importance of closer follow-up during this period. Download PPTDownload PPT Source of Funding: NA © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1238 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Pranjal Agrawal More articles by this author Taylor P. Kohn More articles by this author Rachel S. Rubin More articles by this author Marisa Clifton More articles by this author Maria Uloko More articles by this author Expand All Advertisement PDF downloadLoading ...